Yes, it is.
Using the OpenCDISC Validator Client, you can select the folder that contains all of the files you wish to validate and press the "Open" button on the file dialog to select that folder. You can view a screenshot here. Please note that this folder must only contain files that you wish to have validated, and all of the files must be in the same format.
Using the OpenCDISC Validator command line interface, you may specify a folder as the -source attribute value. You may also specify a folder with a wildcard extension, such as "C:\My Data\*.xpt" to select only the SAS Transport files in that folder. We intend to extend this functionality to the Client in the future.
In either case, the validation is run against all of the relevant files, and the resulting log contains a summary of all of the applicable validations.
Regards,
Tim
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Is it possible to run validation for all or several selected files in a folder?