Error Message when I validate the define.xml 2.1

Is this the issue of P21 bug or define.xml syntax issue?

AppId: us-east-1:afa1e0dc-841c-42d9-babf-764e9c6589d8
PinnacleId: xinhua.zhou@immunogen.com
Application Version: 4.0.2
Platform: win32
Architecture: ia32
Release: 10.0.19045
Free Memory: 6401458176
Total Memory: 17013338112
CPUs: 8
RDP: false
Citrix: false
ErrorId: e18488b435720efb97c5db29319e600c
Meta: {"additionalInfo":[],"exception":"Error code: 56 message: Failed core process.","isError":true,"message":{"current":0,"error":{"cause":{"cause":null,"localizedMessage":null,"message":null,"stackTrace":[{"className":"sun.nio.fs.WindowsFileSystem","fileName":"WindowsFileSystem.java","lineNumber":247,"methodName":"getPath","nativeMethod